This prospective clinical study evaluates the role of individualized homeopathic medicines in the management of generalized anxiety and health-related worries. The study included 60 adult patients aged 20–55 years suffering from anxiety symptoms related to health concerns, examined over 6 months. Each participant received individualized homeopathic remedies based on the totality of symptoms, with follow-up every four weeks. Anxiety levels were assessed using the Generalized Anxiety Disorder Scale (GAD-7) and Health Anxiety Inventory (HAI). Significant improvement was observed, with mean GAD-7 scores reducing from 15.6 ± 3.2 to 6.2 ± 2.1 (p < 0.001), and HAI scores from 19.8 ± 4.4 to 8.9 ± 3.1. Remedies most often indicated were Argentum nitricum, Arsenicum album, Phosphorus, and Calcarea carbonica. The study concludes that individualized homeopathic intervention can significantly reduce anxiety levels and health-related worries, offering a safe and holistic management approach in psychosomatic disorders.