<p>The rapid advancement of computational biology, combined with artificial intelligence (AI)-based predictive analytics, has significantly transformed modern healthcare research and clinical practice. The increasing availability of genomic, proteomic, metabolomic, electronic health records (EHRs), and medical imaging datasets has created unprecedented opportunities for data-driven healthcare decision-making. Traditional statistical methods often struggle to process high-dimensional biological datasets characterized by complexity, heterogeneity, and non-linear interactions. Computational biology integrates biological sciences, mathematics, statistics, computer science, and artificial intelligence to develop computational models capable of extracting meaningful biological insights from large-scale datasets. AI-driven predictive analytics has further enhanced this capability by enabling early disease diagnosis, personalized treatment planning, precision medicine, drug discovery, and healthcare resource optimization. Despite these technological advancements, many healthcare organizations continue to face challenges related to data integration, model interpretability, privacy concerns, algorithmic bias, and clinical implementation. Therefore, an empirical investigation is necessary to understand how computational biology and AI-based predictive analytics collectively influence healthcare outcomes, clinical efficiency, and decision-making quality.</p>

<p><strong>Objectives: </strong>The primary objective of this study is to empirically examine the impact of computational biology and AI-based predictive analytics on healthcare outcomes. Specifically, the study investigates the influence of computational biology on disease prediction accuracy, clinical decision support, personalized medicine, healthcare operational efficiency, and patient satisfaction. Additionally, it evaluates the effectiveness of AI-based predictive analytics in improving healthcare quality, reducing diagnostic errors, and supporting evidence-based clinical decisions.</p>

<p><strong>Methodology: </strong>The study adopts a quantitative, cross-sectional research design. Primary data will be collected from approximately 200 healthcare professionals, including physicians, biomedical researchers, hospital administrators, clinical laboratory specialists, bioinformaticians, and healthcare data analysts, using a structured questionnaire measured on a five-point Likert scale. Stratified random sampling will ensure representation across different healthcare institutions. Descriptive statistics, reliability analysis using Cronbach&#39;s alpha, exploratory factor analysis, Pearson correlation, multiple regression analysis, ANOVA, and Structural Equation Modeling (SEM) will be employed using SPSS (Version 29) and AMOS to test the proposed hypotheses.</p>

<p><strong>Contribution: </strong>This research contributes to the growing literature on computational biology and AI in healthcare by proposing an integrated empirical framework linking computational biology capabilities with AI-driven predictive analytics and healthcare outcomes. The study offers theoretical insights into interdisciplinary healthcare innovation while providing practical recommendations for hospital administrators, policymakers, biomedical researchers, and technology developers seeking to implement AI-enabled computational solutions in clinical environments.</p>

<p><strong>Expected Outcomes: </strong>The study is expected to demonstrate that computational biology significantly enhances disease prediction, personalized medicine, and healthcare decision-making through AI-based predictive analytics. Furthermore, AI-driven computational models are anticipated to improve diagnostic accuracy, optimize healthcare resource utilization, reduce treatment delays, and support precision medicine initiatives. The findings are expected to guide healthcare institutions in developing evidence-based digital transformation strategies while promoting responsible and ethical AI adoption in healthcare systems.</p>